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Stress, cortisol, and other appetite‐related hormones: Prospective prediction of 6‐month changes in food cravings and weight
Author(s) -
Chao Ariana M.,
Jastreboff Ania M.,
White Marney A.,
Grilo Carlos M.,
Sinha Rajita
Publication year - 2017
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21790
Subject(s) - appetite , ghrelin , craving , medicine , weight gain , hormone , prospective cohort study , leptin , endocrinology , food craving , longitudinal study , hydrocortisone , weight loss , chronic stress , morning , obesity , psychology , body weight , psychiatry , addiction , pathology
Objective To examine whether baseline chronic stress, morning cortisol, and other appetite‐related hormones (leptin, ghrelin, and insulin) predict future weight gain and food cravings in a naturalistic, longitudinal, 6‐month follow‐up study. Methods A prospective community cohort of 339 adults (age 29.1 ± 9.0 years; BMI = 26.7 ± 5.4 kg/m 2 ; 56.9% female; 70.2% white) completed assessments at baseline and 6‐month follow‐up. Fasting blood draws were used to assess cortisol and other appetite‐related hormone levels at baseline. At baseline and follow‐up, body weight was measured, and the Cumulative Adversity Interview and Food Craving Inventory were administered. Data were analyzed using linear mixed models adjusting for demographic and clinical covariates. Results Over the 6‐month period, 49.9% of the sample gained weight. Food cravings and chronic stress decreased over 6 months ( P s < 0.05). However, after adjusting for covariates, individuals with higher baseline total ghrelin had significantly higher food cravings at 6 months ( P = 0.04). Furthermore, higher cortisol, insulin, and chronic stress were each predictive of greater future weight gain ( P s < 0.05). Conclusions These results suggest that ghrelin plays a role in increased food cravings and reward‐driven eating behaviors. Studies are needed that examine the utility of stress reduction methods for normalizing disrupted cortisol responses and preventing future weight gain.