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Metabolically healthy obesity and incident chronic kidney disease: The role of systemic inflammation in a prospective study
Author(s) -
Lin Lin,
Peng Kui,
Du Rui,
Huang Xiaolin,
Lu Jieli,
Xu Yu,
Xu Min,
Chen Yuhong,
Bi Yufang,
Wang Weiqing
Publication year - 2017
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21768
Subject(s) - medicine , renal function , kidney disease , creatinine , systemic inflammation , prospective cohort study , odds ratio , confidence interval , body mass index , inflammation , c reactive protein , obesity , albuminuria , gastroenterology , cohort , cohort study , population , environmental health
Objective To investigate the association between the metabolically healthy obesity (MHO) phenotype and incident chronic kidney disease (CKD) in a Chinese population and whether systemic inflammation affects this association. Methods A cohort study was performed with 2,491 Chinese adults. Body mass index ≥ 25.0 kg/m 2 was defined as obesity. CKD was defined as estimated glomerular filtration rate < 60 mL/min per 1.73 m 2 or urinary albumin‐to‐creatinine ratio ≥ 30 mg/g. High‐sensitivity C‐reactive protein (hsCRP) was used as a surrogate marker of systemic inflammation. Results Over a median follow‐up period of 3.9 years, 243 of 2,491 participants developed incident CKD (9.8%). Compared with metabolically healthy nonobesity (MHNO), MHO was associated with incident CKD (odds ratio [OR] = 1.65, 95% confidence interval [CI] 1.01‐2.69), but not after adjustment for hsCRP. The MHO/hsCRP ≥ 0.20 mg/L group, but not the MHO/hsCRP < 0.20 mg/L group, had an increased OR for incident CKD (OR = 2.66, 95% CI 1.37‐5.14), with the MHNO/hsCRP < 0.20 mg/L group as the reference. Conclusions MHO was significantly associated with incident CKD, and the level of systemic inflammation partially explained this association.

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