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Adults with initial metabolic syndrome have altered muscle deoxygenation during incremental exercise
Author(s) -
Machado Alessandro da Costa,
Barbosa Thales Coelho,
Kluser Sales Allan Robson,
de Souza Marcio Nogueira,
da Nóbrega Antonio Claudio Lucas,
Silva Bruno Moreira
Publication year - 2017
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21744
Subject(s) - deoxygenation , medicine , incremental exercise , metabolic syndrome , respiratory exchange ratio , metabolic equivalent , anaerobic exercise , cardiology , aerobic exercise , endocrinology , physical therapy , heart rate , chemistry , blood pressure , biochemistry , physical activity , obesity , catalysis
Objective Reduced aerobic power is independently associated with metabolic syndrome (MetS) incidence and prevalence in adults. This study investigated whether muscle deoxygenation (proxy of microvascular O 2 extraction) during incremental exercise is altered in MetS and associated with reduced oxygen consumption ( V ˙ O 2peak ). Methods Twelve men with initial MetS (no overt diseases and medication‐naive; mean ± SD, age 38 ± 7 years) and 12 healthy controls (HCs) (34 ± 7 years) completed an incremental cycling test to exhaustion, in which pulmonary ventilation and gas exchange (metabolic analyzer), as well as vastus lateralis deoxygenation (near infrared spectroscopy), were measured. Results Subjects with MetS, in contrast to HCs, showed lower V ˙ O 2peak normalized to total lean mass, similar V ˙ O 2 response to exercise, and earlier break point (BP) in muscle deoxygenation. Consequently, deoxygenation slope from BP to peak exercise was greater. Furthermore, absolute V ˙ O 2peak was positively associated with BP in correlations adjusted for total lean mass. Conclusions MetS, without overt diseases, altered kinetics of muscle deoxygenation during incremental exercise, particularly at high‐intensity exercise. Therefore, the balance between utilization and delivery of O 2 within skeletal muscle is impaired early in MetS natural history, which may contribute to the reduction in aerobic power.