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Insulin resistance and its association with catch‐up growth in C hinese children born small for gestational age
Author(s) -
Liu Chunhua,
Wu Baiyan,
Lin Niyang,
Fang Xiaoyi
Publication year - 2017
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21683
Subject(s) - small for gestational age , insulin resistance , medicine , birth weight , gestational age , weight gain , insulin , endocrinology , pregnancy , body weight , biology , genetics
Objective To assess insulin resistance and β‐cell function from birth to age 4 years and to examine their associations with catch‐up growth (CUG) in Chinese small‐for‐gestational‐age (SGA) children. Methods Weight and height were measured yearly from birth to age 4 years, and transformed into age‐ and gender‐adjusted SD scores. Fasting serum insulin and glucose were measured, and fasting insulin resistance and β‐cell function were estimated using the homeostasis model assessment (HOMA). Results The mean HOMA‐IR of the SGA group was significantly lower than that of the appropriate‐for‐gestational‐age (AGA) group at ages 2 and 3 years old, and the mean HOMA% of the SGA group was significantly lower than that of the AGA group at age 4 years old. At 4 years of age, HOMA for insulin resistance was positively correlated with the height gain and SD of height gain between 0 and 5 months, and HOMA% was positively correlated with the weight gain and SD of weight gain between 6 and 12 months in SGA children. Conclusions SGA children with CUG show a greater propensity to develop insulin resistance than AGA children between ages 2 and 4 years old. HOMA parameters are related to CUG in the first year of life.