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Relationship between obesity and anti‐Müllerian hormone in reproductive‐aged African American women
Author(s) -
Bernardi Lia A.,
Carnethon Mercedes R.,
de Chavez Peter J.,
Ikhena Deborah E.,
Neff Lisa M.,
Baird Donna D.,
Marsh Erica E.
Publication year - 2017
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21681
Subject(s) - medicine , anti müllerian hormone , body mass index , obesity , underweight , adipokine , adiponectin , anthropometry , ovarian reserve , leptin , gynecology , endocrinology , obstetrics , hormone , infertility , pregnancy , overweight , insulin resistance , biology , genetics
Objective To determine whether there is an association between obesity and anti‐Müllerian hormone (AMH) among reproductive‐aged African American women (AAW). Methods From the women participating in an ongoing National Institute of Environmental Health Sciences study, 1,654 AAW aged 23 to 35 were included in this study. Anthropometric measurements, personal health information, and serum AMH and adipokine levels were analyzed. Results The median body mass index (BMI) was 32.4 kg/m 2 , and the median AMH was 3.18 ng/mL. Participants with obesity had AMH concentrations that were 23.7% lower than those with a BMI ≤25 kg/m 2 (2.9 ng/mL vs. 3.8 ng/mL). In multivariable linear regression models, current BMI ( β = − 0.015; 95% CI − 0.021 to − 0.009), BMI at age 18 ( β = − 0.016; 95% CI − 0.024 to − 0.008), heaviest reported lifetime weight ( β = − 0.002; 95% CI − 0.003 to − 0.001), and leptin ( β = − 0.016; 95% CI − 0.025 to − 0.007) were inversely associated with AMH. There was no significant association between adiponectin and AMH. AMH was significantly lower (mean log = 0.91, SE = 0.11) in participants with obesity at age 18 and at enrollment when compared with those who were underweight or normal weight at age 18 but had obesity at enrollment (mean log = 1.16, SE = 0.12). Conclusions In reproductive‐aged AAW there is a significant association between obesity and AMH, suggesting that excess adiposity may compromise ovarian reserve. Effects of obesity on AMH may be cumulative.