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Increased aerobic capacity reduces susceptibility to acute high‐fat diet‐induced weight gain
Author(s) -
Matthew Morris E.,
Meers Grace M.E.,
Koch Lauren G.,
Britton Steven L.,
MacLean Paul S.,
Thyfault John P.
Publication year - 2016
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21564
Subject(s) - weight gain , thermogenesis , adipose tissue , obesity , endocrinology , medicine , aerobic capacity , brown adipose tissue , lean body mass , zoology , body weight , chemistry , biology
Objective Aerobic capacity is the most powerful predictor of all‐cause mortality in humans; however, its role in the development of obesity and susceptibility for high‐fat diet (HFD)‐induced weight gain is not completely understood. Methods Herein, a rodent model system of divergent intrinsic aerobic capacity [high capacity running (HCR) and low capacity running (LCR)] was utilized to evaluate the role of aerobic fitness on 1‐week HFD‐induced (45% and 60% kcal) weight gain. Food/energy intake, body composition analysis, and brown adipose tissue gene expression were assessed as important potential factors involved in modulating HFD‐induced weight gain. Results HCR rats had reduced 1‐week weight gain on both HFDs compared with LCR. Reduced HFD‐induced weight gain was associated with greater adaptability to decrease food intake following initiation of the HFDs. Further, the HCR rats were observed to have reduced feeding efficiency and greater brown adipose mass and expression of genes involved in thermogenesis. Conclusions Rats with high intrinsic aerobic capacity have reduced susceptibility to 1‐week HFD‐induced weight gain, which is associated with greater food intake adaptability to control intake of energy‐dense HFDs, reduced weight gain per kcal consumed, and greater brown adipose tissue mass and thermogenic gene expression.