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Non‐hematopoietic effects of endogenous erythropoietin on lean mass and body weight regulation
Author(s) -
Reinhardt Martin,
Dey Soumyadeep,
Tom Noguchi Constance,
Zhang Yuanyuan,
Krakoff Jonathan,
Thearle Marie S.
Publication year - 2016
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21537
Subject(s) - erythropoietin , medicine , leptin , endocrinology , lean body mass , obesity , body mass index , body weight
Objective To investigate the concurrent relationships between human plasma erythropoietin concentrations and energy expenditure (EE), body composition, plasma leptin concentrations, and associations with weight change. Methods Plasma to measure erythropoietin and leptin; data for body composition; 24‐h EE measured in a whole‐room calorimeter; and 75 g oral glucose tolerance testing were available from 109 full‐heritage Pima Indians (55% male) from a larger study designed to understand the causes of obesity. Seventy‐nine subjects had data for weight at a later visit (mean follow‐up = 4.3 ± 1.9 years) to calculate percent weight change per year. Results Erythropoietin, adjusted for covariates, correlated with 24‐h EE ( r = 0.26, P = 0.007), sleeping EE ( r = 0.29, P = 0.003), fat‐free mass ( r = 0.19, P = 0.05), and fat mass ( r = 0.27, P = 0.005), but not insulin or glucose measures. The association of erythropoietin with 24‐h EE was fully mediated by fat‐free mass. Erythropoietin associated with leptin in women ( ρ = 0.36, P = 0.01), but not in men ( P = 0.9), independently from fat mass. The association of erythropoietin with percent weight change per year was in opposing directions (interaction: P = 0.002) in males ( r = −0.35, P = 0.02) versus females ( r = 0.37, P = 0.02). Conclusions Non‐hematopoietic endogenous erythropoietin action may be involved in body weight regulation in opposing directions in men and women, i.e., weight loss in men and weight gain in women.