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Obesity and Age‐Related Changes in Markers of Oxidative Stress and Inflammation Across Four Generations
Author(s) -
Hulsegge Gerben,
HerberGast GerrieCor M.,
Spijkerman Annemieke M.W.,
Susan H.,
Picavet J.,
van der Schouw Yvonne T.,
Bakker Stephan J.L.,
Gansevoort Ron T.,
Dollé Martijn E.T.,
Smit Henriette A.,
Monique Verschuren W.M.
Publication year - 2016
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21515
Subject(s) - uric acid , obesity , body mass index , medicine , oxidative stress , inflammation , c reactive protein , population , endocrinology , physiology , environmental health
Objective The prevalence of obesity increases with age and is higher in each younger generation (unfavorable generation shift). This may influence patterns of oxidative stress and inflammation. Age‐related changes and generation shifts in markers of oxidative stress and inflammation were investigated, specifically addressing the role of body mass index (BMI). Methods Four generations (aged 26–35, 36–45, 46–55, and 56–65 at baseline) ( N = 5,155) were examined every 5 years for 15 years between 1993 and 2012. Random coefficient analyses were used to study age‐related changes and generation shifts in BMI, γ‐glutamyltransferase (GGT), uric acid (UA), and C‐reactive protein (CRP). Results Levels of BMI, UA, and CRP increased in all generations up to age 75, whereas GGT increased up to age 55. No consistent generation shifts were observed for GGT, UA, and CRP ( P ≥ 0.05). Participants with a stable BMI (change ≤1 kg/m 2 /15 years) had either no or small increases with age in GGT, UA, and CRP, whereas participants with increasing BMI (increase >1 kg/m 2 /15 years) had much larger increases ( P < 0.01). Conclusions The unfavorable age‐related changes in obesity‐related biochemical markers, particularly among individuals with increasing BMI, show the importance of maintaining a healthy weight to improve population levels of oxidative stress and inflammation.