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Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study
Author(s) -
CelisMorales Carlos,
Marsaux Cyril F.M.,
Livingstone Katherine M.,
NavasCarretero Santiago,
SanCristobal Rodrigo,
O'donovan Clare B.,
Forster Hannah,
Woolhead Clara,
Fallaize Rosalind,
Macready Anna L.,
Kolossa Silvia,
Hallmann Jacqueline,
Tsirigoti Lydia,
Lambrinou Christina P.,
Moschonis George,
Godlewska Magdalena,
Surwiłło Agnieszka,
Grimaldi Keith,
Bouwman Jildau,
Manios Yannis,
Traczyk Iwona,
Drevon Christian A.,
Parnell Laurence D.,
Daniel Hannelore,
Gibney Eileen R.,
Brennan Lorraine,
Walsh Marianne C.,
Gibney Mike,
Lovegrove Julie A.,
Martinez J. Alfredo,
Saris Wim H.M.,
Mathers John C.
Publication year - 2016
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21422
Subject(s) - fto gene , waist , obesity , allele , medicine , genotype , anthropometry , body mass index , physical activity , endocrinology , polymorphism (computer science) , genetics , biology , physical therapy , gene
Objective To examine whether the effect of FTO loci on obesity‐related traits could be modified by physical activity (PA) levels in European adults. Methods Of 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self‐reported via the Internet. Results FTO genotype was associated with a higher body weight [ β : 1.09 kg per risk allele, (95% CI: 0.14‐2.04), P = 0.024], BMI [ β : 0.54 kg m −2 , (0.23‐0.83), P < 0.0001], and WC [ β : 1.07 cm, (0.24‐1.90), P = 0.011]. Moderate‐equivalent PA attenuated the effect of FTO on BMI ( P [interaction] = 0.020). Among inactive individuals, FTO increased BMI by 1.06 kg m −2 per allele ( P = 0.024), whereas the increase in BMI was substantially attenuated among active individuals (0.16 kg m −2 , P = 0.388). We observed similar effects for WC ( P [interaction] = 0.005): the FTO risk allele increased WC by 2.72 cm per allele among inactive individuals but by only 0.49 cm in active individuals. Conclusions PA attenuates the effect of FTO genotype on BMI and WC. This may have important public health implications because genetic susceptibility to obesity in the presence of FTO variants may be reduced by adopting a physically active lifestyle.