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Mid‐adulthood cardiometabolic risk factor profiles of sarcopenic obesity
Author(s) -
Ma Jiantao,
Hwang ShihJen,
McMahon Gearoid M.,
Curhan Gary C.,
Mclean Robert R.,
Murabito Joanne M.,
Fox Caroline S.
Publication year - 2016
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21356
Subject(s) - sarcopenic obesity , medicine , sarcopenia , obesity , diabetes mellitus , type 2 diabetes , metabolic syndrome , risk factor , endocrinology
Objective Midlife and contemporaneous cardiometabolic risk factors associated with sarcopenic obesity were examined. Methods Utilizing BMI and sex‐specific 24‐h urinary creatinine excretion, 1,019 participants from the Framingham cohorts were categorized as non‐sarcopenia non‐obese (NSNO), non‐obese sarcopenia, non‐sarcopenic obesity, and sarcopenic obesity. Cardiometabolic risk factors were quantified by standard laboratory assessment cross‐sectionally and 10, 20, and 30 years before sarcopenic obesity assessment. Results NSNO, sarcopenia, obesity, and sarcopenic obesity accounted for 30.0%, 39.6%, 20.0%, and 10.4% of study participants, respectively. Cross‐sectionally, participants with sarcopenic obesity had a higher proportion of hypertension, metabolic syndrome, and type 2 diabetes than those with NSNO or sarcopenia (all P < 0.03). Similar patterns were observed retrospectively at 10, 20, and 30 years. Compared with NSNO or sarcopenia, sarcopenic obesity was associated with a higher prevalence of type 2 diabetes at 10 years and hypertension and metabolic syndrome at all three time points before baseline (all P < 0.03). Individuals with sarcopenic obesity had more type 2 diabetes than those with obesity alone at baseline and 10 years prior (all P < 0.001). Conclusions Older adults with sarcopenic obesity had more adverse midlife cardiometabolic risks, particularly diabetes 10 years earlier, which suggests the importance of early identification of risk factors associated with sarcopenic obesity.