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Sugar‐ and artificially sweetened beverages and intrahepatic fat: A randomized controlled trial
Author(s) -
Campos Vanessa,
Despland Camille,
Brandejsky Vaclav,
Kreis Roland,
Schneiter Philippe,
Chiolero Arnaud,
Boesch Chris,
Tappy Luc
Publication year - 2015
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21310
Subject(s) - overweight , medicine , obesity , randomized controlled trial , adipose tissue , zoology , endocrinology , biology
Objective To test the hypothesis that substituting artificially sweetened beverages (ASB) for sugar‐sweetened beverages (SSB) decreases intrahepatocellular lipid concentrations (IHCL) in overweight subjects with high SSB consumption. Methods About 31 healthy subjects with BMI greater than 25 kg/m 2 and a daily consumption of at least 660 ml SSB were randomized to a 12‐week intervention in which they replaced SSBs with ASBs. Their IHCL (magnetic resonance spectroscopy), visceral adipose tissue volume (VAT; magnetic resonance imaging), food intake (2‐day food records), and fasting blood concentrations of metabolic markers were measured after a 4‐week run‐in period and after a 12‐week period with ASB or control (CTRL). Results About 27 subjects completed the study. IHCL was reduced to 74% of the initial values with ASB ( N = 14; P < 0.05) but did not change with CTRL. The decrease in IHCL attained with ASB was more important in subjects with IHCL greater than 60 mmol/l than in subjects with low IHCL. ALT decreased significantly with SSB only in subjects with IHCL greater than 60 mmol/l. There was otherwise no significant effect of ASB on body weight, VAT, or metabolic markers. Conclusions In subjects with overweight or obesity and a high SSB intake, replacing SSB with ASB decreased intrahepatic fat over a 12‐week period.