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Lean body mass, not FFA , predicts VLDL‐TG secretion rate in healthy men
Author(s) -
Søndergaard Esben,
Nellemann Birgitte,
Sørensen Lars Peter,
Christensen Britt,
Gormsen Lars Christian,
Nielsen Søren
Publication year - 2015
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21108
Subject(s) - very low density lipoprotein , medicine , endocrinology , triglyceride , lean body mass , chemistry , body mass index , lipoprotein , cholesterol , body weight
Objective Triglyceride is a risk factor for cardiovascular disease. However, the impact of body composition and free fatty acid (FFA) levels on very‐low‐density‐lipoprotein triglyceride (VLDL‐TG) secretion remains controversial. The aim was to identify predictors of VLDL‐TG secretion in a data set compiled from seven previously published studies. Methods VLDL‐TG kinetics was studied in 96 healthy men covering a wide span in body composition. A primed‐constant infusion of ex vivo labeled [1‐ 14 C]‐triolein VLDL‐TG was used. Body composition was determined by dual X‐ray absorptiometry and computed tomography scanning. Energy expenditure was measured by indirect calorimetry. Palmitate flux was measured by a [9,10‐ 3 H]‐palmitate infusion. Results VLDL‐TG secretion rate correlated significantly with body mass index (BMI), lean body mass (LBM), total fat mass, resting energy expenditure (REE), and insulin. A trend toward an inverse relationship between VLDL‐TG secretion rate and FFA concentration was observed. In mixed model linear regression analysis, VLDL‐TG secretion rate was positively associated with LBM ( P = 0.03), and VLDL‐TG clearance rate was inversely related to total fat mass ( P < 0.01). Conclusions LBM is a predictor of VLDL‐TG secretion in healthy men, whereas FFA availability is not associated with VLDL‐TG secretion. The work suggests reporting VLDL‐TG secretion rates normalized for LBM when comparing subjects with differences in body composition.