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Adults with long‐duration type 2 diabetes have blunted glycemic and β ‐Cell function improvements after bariatric surgery
Author(s) -
Khanna Vishesh,
Malin Steven K.,
Bena James,
Abood Beth,
Pothier Claire E.,
Bhatt Deepak L.,
Nissen Steven,
Watanabe Richard,
Brethauer Stacy A.,
Schauer Philip R.,
Kirwan John P.,
Kashyap Sangeeta R.
Publication year - 2015
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21021
Subject(s) - medicine , type 2 diabetes , incretin , diabetes mellitus , weight loss , glycemic , insulin , body mass index , endocrinology , obesity
Objective This study investigated the effect of type 2 diabetes duration on glucose regulation 24 months post‐bariatric surgery. Methods Twenty‐seven adults with short‐ (<5 years) and long‐duration (≥10 years) type 2 diabetes received a mixed‐meal tolerance test at baseline and 24 months postsurgery. Body weight, insulin sensitivity, first‐ and second‐phase meal‐stimulated insulin secretion, disposition index (i.e., DI or pancreatic β ‐cell function), and incretin responses were examined. Results Adults with short‐duration type 2 diabetes had better HbA 1c , greater insulin secretory capacity, and greater DI compared with adults with long‐duration type 2 diabetes, despite similar weight loss and incretin responses. Diabetes duration correlated with smaller improvements in HbA 1c and DI but not weight loss. Conclusions Enhanced β ‐cell function characterizes the effect of bariatric surgery in adults with diabetes for <5 years, independent of weight loss or incretins. Additional therapy postsurgery may be required to improve glycemia for people with long‐standing type 2 diabetes.