Premium
Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet‐induced obese rats
Author(s) -
Cluny Nina L.,
Eller Lindsay K.,
Keenan Catherine M.,
Reimer Raylene A.,
Sharkey Keith A.
Publication year - 2015
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21017
Subject(s) - obesity , gut flora , hormone , genetic predisposition , medicine , endocrinology , biology , physiology , immunology , disease
Objective Oligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effect of OFS in diet‐induced obese (DIO) and diet‐resistant (DR) rats. Methods Adult, male DIO, and DR rats were randomized to: [1][Levin BE, 2010] high‐fat/high‐sucrose (HFS) diet or [2][Wing RR, 2001] HFS diet + 10% OFS for 6 weeks. Body composition, food intake, gut microbiota, plasma gut hormones, and cannabinoid CB 1 receptor expression in the nodose ganglia were measured. Results OFS reduced body weight, energy intake, and fat mass in both phenotypes ( P < 0.05). Select gut microbiota differed in DIO versus DR rats ( P < 0.05), the differences being eliminated by OFS. OFS did not modify plasma ghrelin or CB 1 expression in nodose ganglia, but plasma levels of GIP were reduced and PYY were elevated ( P < 0.05) by OFS. Conclusions OFS was able to reduce body weight and adiposity in both prone and resistant obese phenotypes. OFS‐induced changes in gut microbiota profiles in DIO and DR rats, along with changes in gut hormone levels, likely contribute to the sustained lower body weights.