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High adipose LPL activity and adipocyte hypertrophy reduce visceral fat and metabolic risk in obese, older women
Author(s) -
Serra Monica C.,
Ryan Alice S.,
Sorkin John D.,
Favor Knachelle H.,
Goldberg Andrew P.
Publication year - 2015
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20998
Subject(s) - adipose tissue , medicine , endocrinology , adipocyte , abdominal obesity , obesity , triglyceride , intra abdominal fat , muscle hypertrophy , metabolic syndrome , visceral fat , insulin resistance , cholesterol
Objective To determine whether higher subcutaneous adipose tissue lipoprotein lipase activity (AT‐LPLA) is associated with greater triglyceride (TG) storage in subcutaneous adipose tissue (SAT), thereby reducing visceral adipose tissue (VAT) accumulation and metabolic dysfunction. Methods Obese postmenopausal women (60 ± 1 years, mean ± SEM; N = 101) had body composition measured by DXA and CT and had fat aspirations to measure fat cell weight (FCW) and AT‐LPLA. Women were ranked by visceral to total abdominal fat ratio (VAT/TAF), and the lowest and highest groups ( n = 24) matched for % fat and age. Results The prevalence of metabolic dysfunction was 7‐ to 10‐fold higher in women with high VAT/TAF ( P s < 0.01). Women with low VAT/TAF had 11% and 6% lower abdominal and gluteal FCW but 28% and 54% higher AT‐LPLA/10 6 cells in abdominal and gluteal fat, respectively. Abdominal FCW correlated with AT‐LPLA in women with low ( r = 0.63, P < 0.01) but not high ( r = 0.14, P = 0.52) VAT/TAF, and these lines differed in slope ( P < 0.05) and intercept ( P < 0.01), suggesting greater capacity for TG storage with low VAT/TAF. There were no relationships between gluteal FCW and AT‐LPLA. The relationship between SAT and abdominal AT‐LPLA ( r = 0.39, P < 0.01) suggests that higher AT‐LPLA promotes TG storage. Conclusions These results suggest that higher AT‐LPLA is associated with SAT adipocyte hypertrophy, which reduces visceral adiposity and metabolic risk in obese, older women.