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Postprandial triglycerides and adipose tissue storage of dietary fatty acids: Impact of menopause and estradiol
Author(s) -
Bessesen Daniel H.,
CoxYork Kimberly A.,
Hernandez Teri Lynn,
Erickson Christopher B.,
Wang Hong,
Jackman Matt R.,
Pelt Rachael E.
Publication year - 2015
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20935
Subject(s) - postprandial , endocrinology , medicine , menopause , triglyceride , adipose tissue , hyperinsulinemia , insulin , cholesterol , insulin resistance
Objectives Postprandial lipemia worsens after menopause, but the mechanism remains unknown. The hypothesized menopause‐related postprandial lipemia would be (1) associated with reduced storage of dietary fatty acids (FA) as triglyceride (TG) in subcutaneous adipose tissue (SAT) and (2) improved by short‐term estradiol (E 2 ). Methods Twenty‐three pre‐ (mean ± SD: 42 ± 4 years) and 22 postmenopausal (55 ± 4 years) women with similar total adiposity were studied. A subset of postmenopausal women ( n = 12) were studied following 2 weeks of E 2 (0.15 mg) and matching placebo in a random, cross‐over design. A liquid meal containing 14 C‐oleic acid traced appearance of dietary FA in: serum (postprandial TG), breath (oxidation), and abdominal and femoral SAT (TG storage). Results Compared to premenopausal women, healthy, lean, postmenopausal women had increased postprandial glucose and insulin and trend for higher TG but had similar dietary FA oxidation and storage. Adipocytes were larger in post‐ compared to premenopausal women, particularly in femoral SAT. Short‐term E 2 reduced postprandial TG and insulin but had no effect on oxidation or storage of dietary FA. E 2 increased the proportion of small adipocytes in femoral (but not abdominal) SAT. Conclusions Short‐term E 2 attenuated menopause‐related increases in postprandial TG and increased femoral adipocyte hyperplasia but not through increased net storage of dietary FA.