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Association of metabolically healthy obesity with subclinical coronary atherosclerosis in a Korean population
Author(s) -
Jung Chang Hee,
Lee Min Jung,
Hwang Jenie Yoonoo,
Jang Jung Eun,
Leem Jaechan,
Yang Dong Hyun,
Kang JoonWon,
Kim Eun Hee,
Park JoongYeol,
Kim HongKyu,
Lee Woo Je
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20883
Subject(s) - medicine , asymptomatic , subclinical infection , cardiology , obesity , coronary atherosclerosis , odds ratio , population , coronary artery disease , stenosis , environmental health
Objective The degree of subclinical coronary atherosclerosis detected by coronary multidetector computed tomography (MDCT) in four groups defined by the state of metabolic health and obesity in an asymptomatic Korean population was compared. Methods The data of 4009 asymptomatic subjects who participated in a routine health screening examination were collected. Significant coronary artery stenosis defined as >50% stenosis, plaque, and coronary artery calcium scores (CACS) were assessed by MDCT. Participants were stratified by BMI (cut‐off value, 25 kg/m 2 ) and metabolically healthy state, which was defined by Wildman criteria. Results Metabolically healthy obese (MHO) subjects had a significantly higher prevalence of significant subclinical coronary atherosclerotic burden compared with metabolically healthy nonobese (MHNO) subjects. The adjusted odds ratios of the MHO group for various coronary MDCT findings (MHNO group as the reference), such as coronary artery stenosis, any plaque, calcified plaque, mixed plaque, CACS > 0, and CACS > 100, were 1.87 (95% CI 1.15‐3.03), 1.31 (1.01‐1.71), 1.40 (1.05‐1.86), 1.57 (1.01‐2.48), 1.38 (1.04‐1.82), and 1.69 (1.03‐2.78), respectively. Conclusions Our data illustrate that MHO subjects have substantial subclinical coronary atherosclerotic burden. Thus, it is important to consider the metabolic health state and obesity in evaluating cardiovascular risk.