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Effects of intensive lifestyle intervention and gastric bypass on aortic stiffness: A 1‐year nonrandomized clinical study
Author(s) -
Gjevestad Espen,
Hjelmesæth Jøran,
Sandbu Rune,
Nordstrand Njord
Publication year - 2015
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20880
Subject(s) - medicine , pulse wave velocity , arterial stiffness , weight loss , group b , pulse pressure , cardiology , blood pressure , obesity
Objective To compare the long‐term effects of Roux‐en‐Y gastric bypass (GBS) and intensive lifestyle intervention (ILI) on aortic stiffness. Methods Nonrandomized clinical trial. Aortic stiffness was assessed by carotid‐femoral pulse wave velocity ( cf PWV) using high‐fidelity applanation tonometry. Results A total of 159 treatment‐seeking morbidly obese patients were included, 82 (54 females) in the GBS‐group and 77 (48 females) in the ILI‐group. Participants in the GBS‐group were younger (42.0 ± 9.9 vs. 46.4 ± 10.5 years), heavier (BMI 45.7 ± 5.3 vs. 42.0 ± 4.9 kg/m 2 ), and had lower systolic pressure (137 ± 19 vs. 145 ± 18 mm Hg) and pulse pressure (57 ± 16 vs. 65 ± 17 mm Hg), all P ≤ 0.006. Mean (SD) cf PWV at baseline was 8.6 ± 1.7 m/s in the GBS‐group and 8.6 ± 1.9 m/s in the ILI‐group, P = 0.959. At follow‐up, mean (95% CI) weight loss was larger in the GBS‐group than in the ILI‐group −43.3 (−46.0 to −40.7) vs. −12.1 (−14.6 to −9.6) kg, P < 0.001. The mean change in cf PWV was −0.02 (−0.31 to 0.27) m/s in the GBS‐group and 0.03 (−0.28 to 0.33) m/s in the ILI‐group, both P ≥ 0.412; adjusted between‐group difference (ANCOVA) 0.05 (−0.40 to 0.49) m/s, P = 0.836. The adjusted regression analysis showed that weight loss was associated with increased cf PWV in the GBS‐group. Conclusions GBS and ILI had no significant long‐term effects on aortic stiffness in treatment‐seeking morbidly obese individuals.