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Stability and changes in metabolically healthy overweight or obesity and risk of future diabetes: Niigata wellness study
Author(s) -
Heianza Yoriko,
Kato Kiminori,
Kodama Satoru,
Suzuki Akiko,
Tanaka Shiro,
Hanyu Osamu,
Sato Koji,
Sone Hirohito
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20855
Subject(s) - overweight , obesity , medicine , diabetes mellitus , environmental health , gerontology , endocrinology
Objective Stability and changes in obesity and metabolic health status from a baseline period and longitudinally investigated their impact on predicting future diabetes were assessed. Methods Studied were 27,478 Japanese individuals without diabetes. Metabolically healthy (MH) was indicated by having ≤1 among impaired fasting glucose, hypertension, hypertriglyceridemia and low HDL cholesterol concentration. Metabolically abnormal (MA) was indicated by having ≥2 of those metabolic abnormalities. A cut‐off value of BMI 25.0 defined overweight or obesity (O) or normal weight (NW). Hazard ratio (HR) for diabetes for a 6‐year period was investigated after changes in phenotypes were assessed during the previous 2 years. Results Compared with maintaining MH‐NW, transitioning to MH‐O from MH‐NW resulted in a multivariate‐adjusted HR of 1.96 (95% CI: 1.18, 3.25) for diabetes. With a stable MH‐O the HR for diabetes was 2.59 (2.00, 3.34) while change from MH‐O to MH‐NW resulted in an HR of 1.30 (0.61, 2.76). Transitioning to MA‐O from MH‐O was associated with an HR of 7.09 (5.41, 9.30). With a stable MA‐O the risk of diabetes was substantially elevated with an HR of 12.5 (10.5, 14.9). Conclusions Examining the transitory nature of apparently benign or unhealthy obese phenotypes was effective for differentiating high‐risk individuals for future diabetes.