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Maternal hypertriglyceridemia: A link between maternal overweight‐obesity and macrosomia in gestational diabetes
Author(s) -
Olmos Pablo R.,
Rigotti Attilio,
Busso Dolores,
Berkowitz Loni,
Santos José L.,
Borzone Gisella R.,
Poblete José A.,
Vera Claudio,
Belmar Cristián,
Goldenberg Denisse,
Samith Bárbara,
Acosta Ana M.,
Escalona Manuel,
Niklitschek Ian,
Mandiola Jorge R.,
Mertens Nicolás
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20816
Subject(s) - overweight , medicine , triglyceride , hypertriglyceridemia , gestational diabetes , birth weight , obesity , gestational age , endocrinology , obstetrics , diabetes mellitus , pregnancy , gestation , cholesterol , biology , genetics
Objective Infants born from overweight and obese mothers with glucose‐controlled gestational diabetes (GDM) tend to be large‐for‐gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels. Methods Two‐hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI: normal weight (BMI = 20–24.9; n = 128), overweight (BMI = 25–29.9; n = 105), and obese (BMI ≥ 30; n = 46). Individual z ‐scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean z ‐scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD. Results In the three groups respectively: LGA (%) = 10.1%, 19.0% and 30.4% ( P = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 ( R SPEARMAN = 0.111, P = 0.027). HbA1c (%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 ( P = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 ( R SPEARMAN = 0.116, P = 0.024). Correlations between triglyceride MZS and NWZS were, respectively: r = 0.12 ( P = NS), r = 0.42 ( P <0.001), and r = 0.47 ( P < 0.001). Conclusions In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.