Premium
Effects of a 1‐year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children
Author(s) -
Blüher Susann,
Panagiotou Grigorios,
Petroff David,
Markert Jana,
Wagner Antje,
Klemm Thorsten,
Filippaios Andreas,
Keller Alexandra,
Mantzoros Christos S.
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20739
Subject(s) - adipokine , adiponectin , medicine , resistin , myokine , leptin , endocrinology , anthropometry , obesity , insulin resistance , skeletal muscle
Objective Exercise improves weight status and metabolism. Irisin, a novel myokine, may be involved in the regulation of metabolic function. The effect of an exercise and dietary lifestyle intervention for 1‐year on irisin, adipokines (leptin, adiponectin, resistin) and inflammatory markers (C‐reactive protein (CRP), soluble tumor necrosis factor receptor II (sTNFR‐II) was evaluated, and predictors of irisin levels were characterized in obese children. Methods Parameters were assessed at baseline and at follow‐up for 65 obese children who completed the program (7–18 years, 54%boys). Their relation to weight status and metabolic risk was analyzed. Results Anthropometric and metabolic parameters improved after completion of the program. Circulating irisin levels at baseline were 111.0 ± 8.0 ng ml −1 and increased after the intervention by 12% [6%, 17%], P = 0.00003. There was no evidence for differences in irisin levels between genders and across age. Moreover, changes in irisin did not correlate with those in BMI‐SDS, adipokines or inflammatory markers. Leptin decreased after the intervention (Δ5.3 ng ml −1 , [3.2, 6.3], P = 10 −7 ). Anthropometric measures were significantly associated with leptin and inflammatory markers. Conclusions A 1‐year long lifestyle intervention program is associated with improvement in anthropometric and metabolic parameters and leads to an elevation in irisin levels in obese children.