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Prepregnancy body mass index and weight change on postpartum diabetes risk among gestational diabetes women
Author(s) -
Liu Huikun,
Zhang Cuiping,
Zhang Shuang,
Wang Leishen,
Leng Junhong,
Liu Dongdong,
Fang Han,
Li Weiqin,
Yu Zhijie,
Yang Xilin,
Dong Ling,
Hu Gang
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20722
Subject(s) - prediabetes , medicine , gestational diabetes , body mass index , obstetrics , pregnancy , weight gain , type 2 diabetes , diabetes mellitus , hazard ratio , weight change , proportional hazards model , obesity , weight loss , gestation , endocrinology , body weight , confidence interval , biology , genetics
Objective To evaluate the effects of prepregnancy BMI and weight change from prepregnancy to postpartum on postpartum type 2 diabetes (T2D) risk among women with gestational diabetes (GDM). Methods A retrospective cohort study in 1,263 GDM women at 1‐5 years after delivery was performed. Cox proportional hazards regression models were used to evaluate the association of prepregnancy BMI and weight change with T2D and prediabetes risks. Results The multivariable‐adjusted hazard ratios based on different levels of prepregnancy BMI (<23, 23‐24.9, 25‐29.9, and ≥30 kg/m 2 ) were 1.00, 1.77, 2.35, and 6.54 ( P trend < 0.001) for incident T2D, and 1.00, 1.46, 1.87, and 1.79 ( P trend < 0.001) for incident prediabetes, respectively. Compared with women with stable weight (±3 kg), those with weight gain ≥7 kg had an 86% and a 32% increased risk of diabetes and prediabetes, and those with weight loss ≥3 kg had a 45% decreased risk of prediabetes. The positive associations of prepregnancy BMI with incident diabetes and prediabetes risk were persistent in women with different levels of weight change (<3 kg and ≥3 kg). Conclusion Prepregnancy obesity and excessive weight gain from prepregnancy to postpartum increase postpartum diabetes and prediabetes risks among GDM women.