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BMI and the risk of colorectal adenoma in African‐Americans
Author(s) -
Ashktorab Hassan,
Paydar Mansour,
Yazdi Shahla,
Namin Hassan Hassanzadeh,
Sanderson Andrew,
Begum Rehana,
Semati Mohammad,
Etaati Firoozeh,
Lee Edward,
Brim Hassan,
Zenebe Anteneh,
NunleeBland Gail,
Laiyemo Adeyinka O.,
Nouraie Mehdi
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20702
Subject(s) - medicine , colonoscopy , body mass index , colorectal cancer , adenoma , gastroenterology , colorectal adenoma , overweight , obesity , family history , cancer
Objectives Obesity is associated with the activation of the molecular pathways that increase the risk of colorectal cancer. Increasing body mass index may accelerate the development of adenomatous polyps, the antecedent lesion of colorectal cancer. The aim of this study was to assess the BMI effect on the risk of colonic polyp and adenoma in African‐American. Methods The records of 923 patients who underwent colonoscopy were examined. Demographic and clinical data were collected before colonoscopy. Polyp and adenoma diagnosis were confirmed by pathology examinations. Results Overall, 43% of the patients were male, median age was 57 years and 77% had BMI ≥ 25.0 kg/m 2 . The frequency of colorectal polyps and adenomas were 61 and 35%, respectively. BMI ≥ 25.0 (OR = 1.61, 95% CI = 1.14‐2.26), smoking (OR = 1.61, 95% CI = 1.15‐2.26) and history of colon polyps (OR = 1.64, 95% CI = 1.09‐2.47) were associated with higher risk of colon polyp. BMI ≥ 25.0 (OR = 1.81, 95% CI = 1.24‐2.62), age (OR = 1.04, 95% CI = 1.02‐2.05 for each year), male gender (OR = 1.38, 95% CI = 1.02‐1.86), and smoking (OR = 1.73, 95% CI = 1.23‐2.42) were associated with higher risk of colon adenoma. Conclusion Male and overweight African‐Americans are at higher risk of colorectal adenoma. The findings of this study could be applied for risk stratification and modifying the colorectal cancer prevention including screening guideline in African Americans.