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Predictors of health‐related quality of life in 500 severely obese patients
Author(s) -
Warkentin Lindsey M.,
Majumdar Sumit R.,
Johnson Jeffrey A.,
Agborsangaya Calypse B.,
RuedaClausen Christian F.,
Sharma Arya M.,
Klarenbach Scott W.,
Birch Daniel W.,
Karmali Shahzeer,
McCargar Linda,
Fassbender Konrad,
Padwal Raj S.
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20694
Subject(s) - medicine , quality of life (healthcare) , fibromyalgia , body mass index , visual analogue scale , depression (economics) , physical therapy , obesity , stroke (engine) , obstructive sleep apnea , mechanical engineering , nursing , engineering , economics , macroeconomics
Objective To characterize health‐related quality of life (HRQL) impairment in severely obese subjects, using several validated instruments. Methods A cross‐sectional analysis of 500 severely obese subjects was completed. Short‐Form (SF)‐12 [Physical (PCS) and Mental (MCS) component summary scores], EuroQol (EQ)‐5D [Index and Visual Analog Scale (VAS)], and Impact of Weight on Quality of Life (IWQOL)‐Lite were administered. Multivariable linear regression models were performed to identify independent predictors of HRQL. Results Increasing BMI was associated with lower PCS (−1.33 points per 5 kg/m 2 heavier; P < 0.001), EQ‐index (−0.02; P < 0.001), EQ‐VAS (−1.71; P = 0.003), and IWQOL‐Lite (−3.72; P = 0.002), but not MCS ( P = 0.69). The strongest predictors (all P < 0.005) for impairment in each instrument were: fibromyalgia for PCS (−5.84 points), depression for MCS (−7.49 points), stroke for EQ‐index (−0.17 points), less than full‐time employment for EQ‐VAS (−7.06 points), and coronary disease for IWQOL‐Lite (−10.86 points). Chronic pain, depression, and sleep apnea were associated with reduced HRQL using all instruments. Conclusion The clinical impact of BMI on physical and general HRQL was small, and mental health scores were not associated with BMI. Chronic pain, depression, and sleep apnea were consistently associated with lower HRQL.