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Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: Findings from the chronic renal insufficiency cohort study
Author(s) -
Wing Maria R.,
Yang Wei,
Teal Valerie,
Navaneethan Sankar,
Tao Kaixiang,
Ojo Akinlolu,
Guzman Nicolas N.,
Reilly Muredach,
Wolman Melanie,
Rosas Sylvia E.,
Cuevas Magda,
Fischer Michael,
Lustigova Eva,
Master Stephen R.,
Xie Dawei,
Appleby Dina,
Joffe Marshall,
Kusek John,
Feldman Harold I,
Raj Dominic S.
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20692
Subject(s) - medicine , fibrinogen , kidney disease , inflammation , body mass index , c reactive protein , quartile , endocrinology , cohort , systemic inflammation , gastroenterology , confidence interval
Objective The race‐specific association of inflammation with adiposity and muscle mass in subjects with chronic kidney disease (CKD) was examined. Methods Plasma concentration of interleukin (IL)−1β, IL‐1 receptor antagonist (IL‐1RA), IL‐6, IL‐10, tumor necrosis factor (TNF)‐α, TGF‐β, high‐sensitivity C‐reactive protein (hs‐CRP), fibrinogen, and serum albumin was measured in 3,939 Chronic Renal Insufficiency Cohort study participants. Bioelectric impedance analysis was used to determine body fat mass (BFM) and fat‐free mass (FFM). Results Plasma levels of hs‐CRP, fibrinogen, IL‐1RA, IL‐6, and TNF‐α increased and serum albumin decreased across the quartiles of body mass index. In multivariable analysis, BFM and FFM were positively associated with hs‐CRP, fibrinogen, IL‐1β, IL‐1RA, and IL‐6. One standard deviation (SD) increase in BFM and FFM was associated with 0.36 (95% confidence interval [CI] = 0.33, 0.39) and 0.26 (95% CI = 0.22, 0.30) SD increase in log‐transformed hs‐CRP, respectively ( P < 0.001). Race stratified analysis showed that the association between biomarkers and BFM and FFM differed by race, with Caucasians, demonstrating a stronger association with markers of inflammation than African Americans. Conclusions BFA and FFM are positively associated with markers of inflammation in patients with CKD. Race stratified analysis showed that Caucasians have a stronger association with markers of inflammation compared to African Americans.