Premium
Estrogen or raloxifene during postmenopausal weight loss: Adiposity and cardiometabolic outcomes
Author(s) -
Pelt R.E.,
Gozansky W.S.,
Wolfe P.,
Kittelson J.M.,
Jankowski C.M.,
Schwartz R.S.,
Kohrt W.M.
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20653
Subject(s) - raloxifene , weight loss , medicine , endocrinology , selective estrogen receptor modulator , placebo , estrogen , abdominal obesity , menopause , lipid profile , obesity , diabetes mellitus , estrogen receptor , metabolic syndrome , breast cancer , alternative medicine , pathology , cancer
Objective Estrogen‐based hormone therapy (HT) attenuates abdominal fat gain after menopause, but whether HT improves abdominal fat loss during weight loss is unknown. It was hypothesized that HT or a selective estrogen receptor modulator (raloxifene) would augment reductions in abdominal visceral fat during weight loss when compared to placebo, potentially increasing improvements in glucose tolerance and lipid profile. Methods Healthy postmenopausal women ( n = 119; age 50‐70 yr) underwent a 6‐month weight‐loss (primarily exercise) intervention with randomization to raloxifene (60 mg/d), HT (conjugated estrogens, 0.625 mg/d), or placebo. Outcomes were change in total and abdominal (visceral and subcutaneous) fat mass, lipid profile, and fasting and post‐challenge glucose and insulin. Results Neither HT nor raloxifene augmented loss of total or abdominal fat mass during exercise‐induced weight loss when compared with placebo. Weight loss‐induced improvements in risk factors were similar among the three groups, except for a greater reduction in fasted glucose in the HT group (difference in change [95%CI] from placebo; −0.40 [−0.76, −0.05]) and greater reductions in LDL (−0.36 [−0.63, −0.09]) and increases in HDL (0.15 [0.07, 0.24]) in both treatment groups. Conclusions Postmenopausal HT and raloxifene did not increase abdominal fat loss during weight loss, but did improve some cardiometabolic outcomes.