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Modifying effect of obesity on the association between sitting and incident diabetes in post‐menopausal women
Author(s) -
Manini Todd M.,
LaMonte Michael J.,
Seguin Rebecca A.,
Manson JoAnn E.,
Hingle Melanie,
Garcia Lorena,
Stefanick Marcia L.,
Rodriguez Beatriz,
Sims Stacy,
Song Yiqing,
Limacher Marian
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20620
Subject(s) - medicine , diabetes mellitus , sitting , incidence (geometry) , type 2 diabetes , obesity , population , relative risk , confidence interval , cohort , body mass index , cohort study , physical therapy , endocrinology , environmental health , physics , pathology , optics
Objective To evaluate the association between self‐reported daily sitting time and the incidence of type 2 diabetes in a cohort of postmenopausal women. Methods Women (N=88,829) without diagnosed diabetes reported the number of hours spent sitting over a typical day. Incident cases of diabetes were identified annually by self‐reported initiation of using oral medications or insulin for diabetes > 14.4 years follow‐up. Results Each hour of sitting time was positively associated with increased risk of diabetes [risk ratio (RR): 1.05; 95% confidence interval (CI): 1.02–1.08]. However, sitting time was only positively associated with incident diabetes in obese women. Obese women reporting sitting 8–11 (RR: 1.08; 95% CI 1.0–1.1), 12–15 (OR: 1.13; 95% CI 1.0–1.2), and ≥16 hours (OR: 1.25; 95% CI 1.0–1.5) hours per day had an increased risk of diabetes compared to women sitting ≤7 hours per day. These associations were adjusted for demographics, health conditions, behaviors (smoking, diet, and alcohol intake), and family history of diabetes. Time performing moderate to vigorous intensity physical activity did not modify these associations. Conclusions Time spent sitting was independently associated with increased risk of diabetes diagnosis among obese women—a population already at high risk of the disease.