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Insulin secretion and its association with physical activity, fitness and screen time in children
Author(s) -
Henderson M.,
GrayDonald K.,
RabasaLhoret R.,
Bastard J.P.,
Barnett T. A.,
Benedetti A.,
Chaput J.P.,
Tremblay A.,
Lambert M.
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20619
Subject(s) - medicine , endocrinology , insulin , insulin sensitivity , body mass index , cohort , area under the curve , obesity , insulin resistance
Objectives To determine the independent associations of moderate to vigorous physical activity (MVPA), fitness, screen time, and adiposity with insulin secretion in children. Design and Methods Caucasian youth ( n = 423/630), 8‐10 years old, with at least one obese biological parent, were studied (QUALITY cohort). Insulin secretion was measured using HOMA2‐%B, area under the curve (AUC) of insulin to glucose over the first 30 minutes (AUC I/G t30min ) of the OGTT and AUC I/G t120min over 2 hours. Fitness was measured by VO 2peak ; percent fat mass (PFM) by DXA; 7‐day MVPA by accelerometry; self‐reported screen time included television, video game, or computer use. Models were adjusted for age, sex, season, puberty, PFM, and insulin sensitivity [IS] (HOMA2‐IS, Matsuda‐ISI). Results PFM was strongly associated with insulin secretion, even after adjustment for IS: for every 1% increase in PFM, insulin secretion increased from 0.3% to 0.8% across indices. MVPA was negatively associated with HOMA2‐%B ( P < 0.05), but not with OGTT‐derived measures. Fitness was negatively associated with AUC I/G t120min ( P < 0.05). Screen time showed a trend toward higher HOMA2‐%B in girls ( P = 0.060). Conclusions In children with an obese parent, lower insulin secretion is associated with lower adiposity, higher MVPA, better fitness, and possibly reduced screen time.