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Prenatal exposure to persistent organic pollutants and rapid weight gain and overweight in infancy
Author(s) -
Valvi Damaskini,
Mendez Michelle Ann,
GarciaEsteban Raquel,
Ballester Ferran,
Ibarluzea Jesús,
Goñi Fernando,
Grimalt Joan O.,
Llop Sabrina,
Marina Loreto Santa,
Vizcaino Esther,
Sunyer Jordi,
Vrijheid Martine
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20603
Subject(s) - overweight , hexachlorobenzene , medicine , pregnancy , birth weight , population , weight gain , breastfeeding , percentile , obesity , pediatrics , environmental health , body weight , pollutant , endocrinology , biology , ecology , statistics , genetics , mathematics
Objective To examine the effects of prenatal exposure to persistent organic pollutants (POPs) on rapid growth in the first 6 months of life and overweight at 14 months of age. Design and Methods In a Spanish birth cohort study, the POPs dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB), and polychlorinated biphenyls (PCBs—congeners 153, 138, 180) were measured in maternal serum collected in the first trimester of pregnancy during 2003–2008. Rapid growth was defined as a z ‐score weight gain >0.67 SD between 6 months of age and birth. Overweight at 14 months was defined as a BMI z ‐score ≥85th percentile. Generalized linear models examined the association between POPs and rapid growth ( N = 1285) and overweight ( N = 1198). Results The analysis population included 24% rapid growers and 30% overweight infants. DDE and HCB were positively associated with rapid growth and with overweight. There was some indication that infant sex and exclusive breastfeeding duration may modify the effects of DDE, and that maternal prepregnancy BMI status may influence the effects of HCB. PCBs were not related to postnatal growth. Conclusion Prenatal exposure to DDE and HCB may be associated with early postnatal growth. Further research is needed to evaluate the persistence of these associations at older ages.