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Bariatric surgery influences the number and quality of oocytes in patients submitted to assisted reproduction techniques
Author(s) -
Christofolini Juliana,
Bianco Bianca,
Santos Gustavo,
Adami Fernando,
Christofolini Denise,
Barbosa Caio Parente
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20590
Subject(s) - medicine , oocyte , infertility , obesity , gynecology , human fertilization , pregnancy , biology , embryo , anatomy , microbiology and biotechnology , genetics
Objective To determine differences in follicle stimulation, oocyte retrieval, maturation, and fertilization among patients who underwent bariatric surgery, obese patients, and patients with 18 < BMI < 30 kg/m² submitted to assisted reproduction techniques and check that these patients may have some impairment in ovarian response. Methods The study comprised three groups: GI: 29 patients who had undergone restrictive and/or malabsorptive bariatric surgery; GII: 57 obese patients (BMI > 30 kg/m²); and GIII: 94 patients (18 < BMI < 30 kg/m²) with infertility due to a male factor. BMI, weight loss until oocyte retrieval, vitamin supplementation, and anemia were evaluated. Data were compared with the number of follicles observed, the number of oocytes retrieved, and the maturation status of these oocytes. Results were analyzed statistically. Results A statistically significant difference in the number of follicles observed by ultrasound ( P < 0.01), the number of oocytes retrieved ( P = 0.013), and the number of metaphase II oocytes ( P < 0.01) between the patients with prior bariatric surgery and both GII and GIII group was found. Conclusions The weight loss resulting from bariatric surgery can be very beneficial to the overall health of the woman, but the reproductive process can be impaired. Bariatric surgery appears to have an important impact on the formation of follicles and oocytes.