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Low‐molecular‐weight adiponectin and high‐molecular‐weight adiponectin levels in relation to diabetes
Author(s) -
Goto Maki,
Goto Atsushi,
Morita Akemi,
Deura Kijo,
Sasaki Satoshi,
Aiba Naomi,
Shimbo Takuro,
Terauchi Yasuo,
Miyachi Motohiko,
Noda Mitsuhiko,
Watanabe Shaw
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20553
Subject(s) - adiponectin , medicine , endocrinology , diabetes mellitus , obesity , insulin resistance
Objective To evaluate the association between adiponectin complexes (high‐molecular‐weight [HMW], middle‐molecular‐weight [MMW], and low‐molecular‐weight [LMW] adiponectin) and diabetes. Design and Methods We conducted a case‐control study, based on a cohort in Saku, Japan. Among 2565 participants, 300 participants with diabetes and 300 matched controls (430 men and 170 women) were analyzed. Results After adjusting for age, physical activity, hypertension, family history, alcohol use, smoking, and menopausal status, total, HMW, and LMW, but not MMW adiponectin levels were inversely associated with diabetes: total adiponectin, odds ratio comparing the highest with the lowest quartiles, 0.46 (95% confidence interval, 0.25–0.82; P for trend = 0.046); HMW, 0.40 (95%CI, 0.22–0.72; P = 0.046); MMW, 1.04 (95%CI, 0.60–1.77; P = 0.81); and LMW, 0.51 (95%CI, 0.29–0.89; P = 0.01). The associations between total and HMW adiponectin and diabetes attenuated after adjustment for BMI ( P = 0.15 and 0.13, respectively), but LMW remained ( P = 0.04). When stratified by sex, LMW adiponectin levels were associated with diabetes in men only. None of the associations were significant after adjustment for HOMA‐IR. Conclusions Decreased LMW, total, and HMW adiponectin levels are associated with diabetes. These associations may be secondary to adiposity or insulin resistance.