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Ethnic differences in the effects of hepatic fat deposition on insulin resistance in nonobese middle school girls
Author(s) -
Wolfgram Peter M.,
Connor Ellen L.,
Rehm Jennifer L.,
Eickhoff Jens C.,
Reeder Scott B.,
Allen David B.
Publication year - 2014
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20521
Subject(s) - medicine , insulin resistance , endocrinology , adiponectin , waist , sex hormone binding globulin , insulin , obesity , hormone , androgen
Objective In nonobese youth, to investigate whether hepatic fat deposition and its metabolic consequences vary between ethnic groups. Design and Methods Thirty‐two nonobese girls (12 Hispanic White [H] and 20 non‐Hispanic White [NHW] girls), aged 11‐14 years old were recruited. Outcome measures were MRI measured hepatic proton density fat fraction (hepatic PDFF), BMI Z ‐score, waist circumference, fasting insulin, glucose, adiponectin, sex hormone‐binding globulin [SHBG], ALT, AST, triglycerides, and HOMA‐IR. Results There were no significant differences in mean BMI Z ‐scores ( P = 0.546) or hepatic PDFF ( P = 0.275) between H and NHW girls; however, H girls showed significant correlations between hepatic PDFF and markers of IR (fasting insulin, HOMA‐IR, adiponectin, SHBG, triglycerides; all P < 0.05), while NHW girls showed no significant correlations. Matched by hepatic PDFF or BMI Z ‐score, H girls had more evidence of IR for a given hepatic PDFF (mean insulin, HOMA‐IR, and SHBG; all P < 0.05) or BMI Z ‐score (mean insulin and HOMA‐IR; all P < 0.01) than NHW girls. Conclusions In nonobese female youth, ethnicity‐related differences in effects of hepatic fat on IR are evident, so that in H girls, a given amount of hepatic fat appears to result in a more predictable and greater degree of IR than in NHW girls.