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Clinical utility and reproducibility of visceral adipose tissue measurements derived from dual‐energy X‐ray absorptiometry in white and African American adults
Author(s) -
Katzmarzyk Peter T.,
Greenway Frank L.,
Heymsfield Steven B.,
Bouchard Claude
Publication year - 2013
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20519
Subject(s) - reproducibility , medicine , receiver operating characteristic , adipose tissue , dual energy x ray absorptiometry , dual energy , prospective cohort study , nuclear medicine , osteoporosis , bone mineral , statistics , mathematics
Objective The purpose of this study was to determine reproducibility and clinical thresholds for DXA‐derived visceral adipose tissue (VAT). Design and Methods The sample included 2317 white and African American adults 18‐74 years of age. VAT areas (cm 2 ) were measured using a Hologic DXA scanner equipped with APEX 4.0 software. Reproducibility was assessed using repeated measurements on 101 participants scanned 14 days apart. Receiver Operating Characteristic (ROC) curves were used to assess clinical utility and select thresholds that identified elevated cardiometabolic risk, defined as the presence of ≥2 risk factors. Results Reproducibility of DXA‐VAT was 8.1%. The areas under the ROC curves ranged from 0.754 in African American men to 0.807 in white women. The thresholds were higher in white men (154 cm 2 ) and women (143 cm 2 ) compared to African American men (101 cm 2 ) and women (114 cm 2 ). Conclusion The results demonstrated that DXA VAT is a useful clinical marker of cardiometabolic risk; however, further research is required to determine associations with health outcomes using longitudinal studies.