z-logo
Premium
Body mass index, gender, and clinical outcome among hypertensive and diabetic patients with stage A/B heart failure
Author(s) -
Ballo Piercarlo,
Betti Irene,
Barchielli Alessandro,
Castelli Gabriele,
Luca Leonardo,
Gheorghiade Mihai,
Zuppiroli Alfredo
Publication year - 2013
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20420
Subject(s) - medicine , asymptomatic , overweight , hazard ratio , heart failure , body mass index , diabetes mellitus , obesity , obesity paradox , cardiology , cohort , endocrinology , confidence interval
Objective The existence of an “obesity paradox” in asymptomatic patients with preclinical heart failure (HF) has not been investigated. The prognostic value of BMI in a cohort of hypertensive and diabetic patients with stage A/B HF enrolled in the PROBE‐HF study was explored. Design and Methods BMI was measured in 1003 asymptomatic subjects (age 66.4 ± 7.8 years, 48% males) with hypertension and/or type 2 diabetes and no clinical evidence of HF. Predefined endpoints were all‐cause mortality and a composite of death and hospitalization for cardiac causes. Results During a follow‐up of 38.5 ± 4.1 months, 33 deaths were observed. Mortality in the normal BMI group (1.6 deaths per 100 patient‐years) did not differ to that in the overweight group (1.1 per 100 patient‐years, p = 0.31), but was higher than that in the obese group (0.4 per 100 patient‐years, p = 0.0089). In multivariable analysis, obesity (hazard ratio [HR] 0.27 [0.09‐0.85], p = 0.025) but not overweight (HR 0.68 [0.32‐1.45], p = 0.32) was associated with lower risk of death. Obesity was also independently associated with reduced risk of the composite endpoint (HR 0.54 [0.28‐0.99], p = 0.047). Conclusion In asymptomatic hypertensive and diabetic patients with preclinical HF, obesity is associated with better survival and reduced risk of events.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here