Premium
Obesity is associated with white matter atrophy: A combined diffusion tensor imaging and voxel‐based morphometric study
Author(s) -
Karlsson Henry K.,
Tuulari Jetro J.,
Hirvonen Jussi,
Lepomäki Virva,
Parkkola Riitta,
Hiltunen Jaana,
Hannukainen Jarna C.,
Soinio Minna,
Pham Tam,
Salminen Paulina,
Nuutila Pirjo,
Nummenmaa Lauri
Publication year - 2013
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20386
Subject(s) - fractional anisotropy , diffusion mri , white matter , voxel , medicine , atrophy , statistical parametric mapping , voxel based morphometry , obesity , endocrinology , pathology , psychology , nuclear medicine , magnetic resonance imaging , radiology
Objective Little is known about the mechanisms by which obesity influences brain structure. In this study, the obesity‐related changes in brain white and gray matter integrity were examined. Design and Methods 23 morbidly obese subjects and 22 nonobese volunteers were studied using voxel‐based analysis of diffusion tensor imaging and of T1‐weighted MRI images. Full‐volume statistical parametric mapping analysis was used to compare fractional anisotropy (FA) and mean diffusivity (MD) values as well as gray (GM) and white matter (WM) density between these groups. Results Obese subjects had lower FA and MD values and lower focal and global GM and WM volumes than control subjects did. The focal structural changes were observed in brain regions governing reward seeking, inhibitory control, and appetite. Regression analysis showed that FA and MD values as well as GM and WM density were negatively associated with body fat percentage. Moreover, the volume of abdominal subcutaneous fat was negatively associated with GM density in most regions. Conclusion These findings imply that changes in GM and WM in obesity may be due to metabolic factors. Atrophy in regions involved in reward processing and appetite control may further promote abnormal reward seeking and eating behavior.