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Effects of risperidone on energy balance in female C57BL/6J mice
Author(s) -
Li Xingsheng,
Johnson Maria S.,
Smith Daniel L.,
Li Yan,
Kesterson Robert A.,
Allison David B.,
Nagy Tim R.
Publication year - 2013
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20350
Subject(s) - endocrinology , medicine , risperidone , weight gain , brown adipose tissue , placebo , hypothalamus , adipose tissue , orexin , resting energy expenditure , energy expenditure , body weight , psychiatry , neuropeptide , schizophrenia (object oriented programming) , receptor , pathology , alternative medicine
Objective To investigate the effect of risperidone on energy expenditure and weight gain in female C57BL/6J mice. Design and Methods Body weight and composition, food intake, energy expenditure, and activity were determined weekly. mRNA expression of uncoupling protein 1 in brown adipose tissue, orexin, and brain‐derived neurotrophic factor in the hypothalamus were quantified using real‐time PCR. Results Risperidone tended to induce a greater body weight gain ( P = 0.052) and significantly higher food intake ( P = 0.038) relative to the placebo‐treated group. Risperidone‐treated mice had a higher resting energy expenditure ( P = 0.001) and total energy expenditure (TEE) ( P = 0.005) than the placebo group. There were no effects of treatment, time, and treatment by time on non‐resting (or activity‐related) energy expenditure between groups. Risperidone‐treated mice showed a significantly lesser locomotor activity than placebo‐treated mice over 3 weeks ( P < 0.001). Risperidone induced a higher UCP1 mRNA ( P = 0.003) and a lower orexin mRNA ( P = 0.001) than placebo. Conclusion Risperidone‐induced weight gain is associated with hyperphagia and a reduction in locomotor activity in C57BL/6J mice. Additionally, higher total and resting energy expenditure were accompanied by higher levels of UCP1 mRNA in BAT. The increased TEE could not offset the total intake of energy through risperidone‐induced hyperphagia, therefore resulting in weight gain in female C57BL/6J mice.