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Genome‐wide association study of genetic factors related to confectionery intake: Potential roles of the ADIPOQ gene
Author(s) -
Wakai Kenji,
Matsuo Keitaro,
Matsuda Fumihiko,
Yamada Ryo,
Takahashi Meiko,
Kawaguchi Takahisa,
Yatabe Yasushi,
Ito Hidemi,
Hosono Satoyo,
Tajima Kazuo,
Naito Mariko,
Morita Emi,
Yin Guang,
Sakamoto Tatsuhiko,
Takashima Naoyuki,
Suzuki Sadao,
Nakahata Noriko,
Mikami Haruo,
Ohnaka Keizo,
Watanabe Yoshiyuki,
Arisawa Kokichi,
Kubo Michiaki,
Hamajima Nobuyuki,
Tanaka Hideo
Publication year - 2013
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20316
Subject(s) - single nucleotide polymorphism , genome wide association study , genetic association , genotyping , minor allele frequency , adiponectin , snp , genetics , medicine , genotype , biology , obesity , gene , insulin resistance
Objective: The excessive consumption of confectionery might have adverse effects on human health. To screen genetic factors associated with confectionery‐intake frequency, a genome‐wide association study (GWAS) in Japan was conducted. Design and Methods: For the discovery phase (stage 1), we conducted a GWAS of 939 noncancer patients in a cancer hospital. Additive models were used to test associations between genotypes of approximately 500,000 single‐nucleotide polymorphisms (SNPs) and the confectionery‐intake score (based on intake frequency). We followed‐up association signals with P < 1 × 10 −5 and minor allele frequency >0.01 in stage 1 by genotyping the SNPs of 4,491 participants in a cross‐sectional study within a cohort (replication phase [stage 2]). Results: We identified 12 SNPs in stage 1 that were potentially related to confectionery intake. In stage 2, this association was replicated for one SNP (rs822396; P = 0.049 for stage 2 and 4.2 × 10 −5 for stage 1+2) in intron 1 of the ADIPOQ gene, which encodes the adipokine adiponectin. Conclusions: Given the biological plausibility and previous relevant findings, the association of an SNP in the ADIPOQ gene with a preference for confectionery is worthy of follow‐up and provides a good working hypothesis for experimental testing.