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Differential associations of leptin with adiposity across early childhood
Author(s) -
Boeke Caroline E.,
Mantzoros Christos S.,
Hughes Michael D.,
L. RifasShiman Sheryl,
Villamor Eduardo,
Zera Chloe A.,
Gillman Matthew W.
Publication year - 2013
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20314
Subject(s) - leptin , medicine , waist , birth weight , endocrinology , weight gain , gestation , obesity , umbilical cord , pregnancy , body weight , biology , anatomy , genetics
Objective To examine associations of perinatal and 3‐year leptin with weight gain and adiposity through 7 years. Design and Methods In Project Viva, plasma leptin from mothers at 26‐28 weeks' gestation ( n = 893), umbilical cord vein at delivery ( n = 540), and children at 3 years ( n = 510) was assessed in relation to BMI z ‐score, waist circumference, skinfold thicknesses, and dual X‐ray absorptiometry body fat. Results 50.1% of children were male and 29.5% non‐white. Mean (SD) maternal, cord, and age 3 leptin concentrations were 22.9 (14.2), 8.8 (6.4), and 1.8 (1.7) ng/ml, respectively, and 3‐ and 7‐year BMI z ‐scores were 0.46 (1.00) and 0.35 (0.97), respectively. After adjusting for parental and child characteristics, higher maternal and cord leptin were associated with less 3‐year adiposity. For example, mean 3‐year BMI z ‐score was 0.5 lower (95% CI: −0.7, −0.2; P ‐trend = 0.003) among children whose mothers' leptin concentrations were in the top versus bottom quintile. In contrast, higher age 3 leptin was associated with greater weight gain and adiposity through age 7 [e.g., change in BMI z ‐score from 3 to 7 years was 0.2 units (95% CI: −0.0, 0.4; P ‐trend =0.05)]. Conclusion Higher perinatal leptin was associated with lower 3‐year adiposity, whereas higher age 3 leptin was associated with greater weight gain and adiposity by 7 years.