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The effects of weight loss on relative bone mineral density in premenopausal women
Author(s) -
Hamilton Kara C.,
Fisher Gordon,
Roy Jane L.,
Gower Barbara A.,
Hunter Gary R.
Publication year - 2013
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.20052
Subject(s) - medicine , weight loss , overweight , bone mineral , body weight , body mass index , endocrinology , obesity , bone density , zoology , osteoporosis , biology
Objective: This study compared BMD relative to body weight following a ∼6‐month weight loss program and a 1‐year weight maintenance phase in premenopausal women and determined whether African American (AA) and European‐American (EA) women's BMD respond similarly during weight loss. Design and Methods: Premenopausal women ( n = 115, 34 ± 5 years) were evaluated in an overweight state (BMI between 27 and 30 kg/m 2 ), following an 800 kcal/day diet/exercise program designed to reduce BMI<25 kg/m 2 , and 1‐year following weight loss. Results: BMD relative to body weight (Z‐scores) increased after weight loss, but decreased during the 1‐year weight maintenance phase. All 1‐year follow‐up BMD Z‐scores were increased (except L1) compared to baseline measurements ( P < 0.05). These sites included the hip neck (+0.088, P = 0.014), total hip (+0.099, P = 0.001), L2 (+0.127, P = 0.013), L3 (+0.135, P = 0.014), and L4 (+0.199, P = 0.002). AAs had significantly higher absolute BMD at all sites ( P < 0.05) compared to EAs, but no time by race interactions were evident during weight loss (except in L3). Conclusion: These results may indicate that weight loss is safe with regard to bone health for overweight premenopausal women.