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Multiple Calvarial Lytic Lesions: A Differential Diagnosis from Early Medieval France (5th to 7th c. AD)
Author(s) -
Bauduer F.,
Bessou M.,
Guyomarc'h P.,
Mercier C.,
Castex D.
Publication year - 2012
Publication title -
international journal of osteoarchaeology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 60
eISSN - 1099-1212
pISSN - 1047-482X
DOI - 10.1002/oa.2256
Subject(s) - skull , sarcoidosis , langerhans cell histiocytosis , differential diagnosis , medical diagnosis , medicine , tuberculosis , paleopathology , radiography , lytic cycle , pathology , dermatology , multiple myeloma , radiology , disease , anatomy , virus , immunology
A skull from the early French Medieval period presenting multiple destructive lesions is investigated. The study of this presumably young female skull suggests a series of possible diagnoses using macroscopic features, standard radiography, CT, and 3D analysis. After a review of the paleopathological and medical literature, the debate focuses on several malignant disorders (cancerous metastases, multiple myeloma), Langerhans cell histiocytosis, and other benign conditions such as infection (especially tuberculosis) or sarcoidosis. Although the definite diagnosis of such paleopathological lesions is not straightforward, Langerhans cell histiocytosis is the most probable diagnosis. Copyright © 2012 John Wiley & Sons, Ltd.