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CT and micro‐CT analysis of a case of Paget's disease ( osteitis deformans ) in the Grant skeletal collection
Author(s) -
Wade A. D.,
Holdsworth D. W.,
Garvin G. J.
Publication year - 2011
Publication title -
international journal of osteoarchaeology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 60
eISSN - 1099-1212
pISSN - 1047-482X
DOI - 10.1002/oa.1111
Subject(s) - radiography , medicine , osteology , differential diagnosis , projectional radiography , radiology , plain radiography , osteitis deformans , computed tomography , paleopathology , conventional radiography , physical examination , disease , anatomy , pathology , paget's disease of bone
Abstract This paper presents a case study in which Paget's disease of bone is differentially diagnosed in an individual from the Grant skeletal collection using non‐destructive computed tomography (CT) and micro‐computed tomography (micro‐CT) analyses of the pubis, in addition to plain film radiography and macroscopic examination. In archaeological and modern osteological samples diagnosis frequently relies on macroscopic examination, plain film radiography and histological examination of bone samples. CT and micro‐CT modalities provide researchers with a non‐destructive view of the internal structure of bone unhampered by the superimposition that is characteristic of plain film radiographs. Given the importance of the increased cortical and trabecular thickness in the differential diagnosis of Paget's disease, these techniques are ideal means by which to non‐destructively examine culturally‐sensitive and scientifically‐valuable human remains for signs of Paget's disease of bone. Copyright © 2009 John Wiley & Sons, Ltd.