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Nutrition intervention to decrease symptoms in patients with advanced heart failure
Author(s) -
Lennie Terry A.,
Moser Debra. K.,
Biddle Martha J.,
Welsh Darlene,
Bruckner Geza G.,
Thomas D. Travis,
Rayens Mary Kay,
Bailey Alison L.
Publication year - 2013
Publication title -
research in nursing and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.836
H-Index - 85
eISSN - 1098-240X
pISSN - 0160-6891
DOI - 10.1002/nur.21524
Subject(s) - medicine , heart failure , placebo , quality of life (healthcare) , randomized controlled trial , physical therapy , nursing , alternative medicine , pathology
For a majority of patients with advanced heart failure, there is a need for complementary, non‐pharmacologic interventions that could be easily implemented by health care providers to provide palliative care. Three major pathologic pathways underlying heart failure symptoms have been identified: fluid overload, inflammation, and oxidative stress. Prior research has demonstrated that three nutrients‐sodium, omega‐3 fatty acids, and lycopene‐can alter these pathologic pathways. Therefore, the purposes of this study are to test the effects of a 6‐month nutrition intervention of dietary sodium reduction combined with supplementation of lycopene and omega‐3 fatty acids on heart failure symptoms, health‐related quality of life, and time to heart failure rehospitalization or all‐cause death. The aims of this double blind‐placebo controlled study are (1) to determine the effects of a 6‐month nutrition intervention on symptom burden (edema, shortness of air, and fatigue) and health‐related quality of life at 3 and 6 months, and time to heart failure rehospitalization or all‐cause death over 12 months from baseline; (2) compare dietary sodium intake, inflammation, and markers of oxidative stress between the nutrition intervention group and a placebo group at 3 and 6 months; and (3) compare body weight, serum lycopene, and erythrocyte omega‐3 index between the nutrition intervention group and a placebo group at 3 and 6 months. A total of 175 patients with advanced heart failure will be randomized to either the nutrition intervention or placebo group. © 2013 Wiley Periodicals, Inc. Res Nurs Health 36:120–145, 2013

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