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High‐density lipoprotein prevents organ damage in endotoxemia
Author(s) -
Lee RuPing,
Lin NienTsung,
Chao YannFen Chiou,
Lin ChiaChin,
Harn HorngJyh,
Chen HsingI
Publication year - 2007
Publication title -
research in nursing and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.836
H-Index - 85
eISSN - 1098-240X
pISSN - 0160-6891
DOI - 10.1002/nur.20187
Subject(s) - nitrite , medicine , creatinine , sepsis , lipoprotein , pathological , high density lipoprotein , infiltration (hvac) , renal function , endocrinology , cholesterol , nitrate , chemistry , physics , organic chemistry , thermodynamics
High‐density lipoprotein (HDL) may decrease organ injury in sepsis. This study was designed using an animal model to mimic people who had a high HDL level and to test HDL effects on preventing organ damage in endotoxemia. Endotoxemia was induced by an infusion of lipopolysac‐charide (LPS) after HDL or LDL administration. Levels of blood biochemical substances, nitrate/nitrite, and TNF‐α in sera were measured. Pathological examinations were performed 72 hours after LPS infusion. HDL decreased the endotoxin‐induced elevation of AST, ALT, BUN, creatinine, LDH, CPK, nitrate/nitrite, and TNF‐α. On histological examination, neutrophil infiltration was lower in the HDL group. HDL had a significant effect in preventing endotoxin‐induced organ damage. © 2007 Wiley Periodicals, Inc. Res Nurs Health 30: 250–260, 2007