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Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon‐26 adenocarcinoma
Author(s) -
Graves Erin,
Hitt Andrew,
Pariza Michael W.,
Cook Mark E.,
McCarthy Donna O.
Publication year - 2005
Publication title -
research in nursing and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.836
H-Index - 85
eISSN - 1098-240X
pISSN - 0160-6891
DOI - 10.1002/nur.20052
Subject(s) - cachexia , gastrocnemius muscle , conjugated linoleic acid , wasting , endocrinology , medicine , tumor necrosis factor alpha , skeletal muscle , myogenesis , colorectal cancer , polyunsaturated fatty acid , linoleic acid , cancer , fatty acid , chemistry , biochemistry
Cancer cachexia is a syndrome of weight loss, muscle wasting, fatigue, and anorexia that occurs in patients with advanced or recurrent solid tumor disease. Tumor necrosis factor‐alpha (TNFα) and prostaglandin E2 (PGE2) have been implicated in the biology of cachexia and serve as possible targets for treatment of this condition. Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid that alters the synthesis of PGE2 and reduces the negative effects of TNF on body weight of healthy mice. We hypothesized that a diet supplemented with .5% CLA might reduce muscle wasting in mice bearing the colon‐26 adenocarcinoma, an animal model of cancer cachexia. CLA preserved gastrocnemius muscle mass and reduced TNF receptors in muscle of tumor‐bearing mice. These data suggest that CLA may preserve muscle mass by reducing the catabolic effects of TNF on skeletal muscle. © 2004 Wiley Periodicals, Inc. Res Nurs Health 28:48–55, 2005