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Exercise capacity and its relationship with body composition and nutrition status in patients with interstitial lung disease
Author(s) -
Rinaldi Sylvia,
Gilliland Jason,
O'Connor Colleen,
Seabrook Jamie A.,
Mura Marco,
Madill Janet
Publication year - 2021
Publication title -
nutrition in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 71
eISSN - 1941-2452
pISSN - 0884-5336
DOI - 10.1002/ncp.10651
Subject(s) - medicine , bioelectrical impedance analysis , body mass index , odds ratio , malnutrition , mass index , vital capacity , interstitial lung disease , gastroenterology , physical therapy , lung , diffusing capacity , lung function
Background Patients with interstitial lung disease (ILD) are known to have diminished exercise ability. This study aimed to explore the relationship between nutrition status and body composition parameters with exercise capacity in ILD patients. A second aim focused on assessing the appropriateness of surrogate markers of nutrition status in ILD patients. Methods Disease severity was determined by the percentage of predicted forced vital capacity. Exercise capacity was determined using 6‐minute walk distance. Nutrition status was assessed using the subjective global assessment (SGA), standardized phase angle (SPhA), and impedance ratio z‐score (z‐IR). Bioelectrical impedance analysis estimated body composition parameters. Results 45 of 79 participants (57%) were malnourished according to the SGA. FFM index z‐score (z‐FFMI) ( r = 0.42, P = .02) and SGA ( r = 0.49, P < .01) were significant predictors of exercise capacity independent of disease severity. Age (odds ratio [OR] = 1.1; 95% CI, 1.01–1.25; P = .04), low body mass index (OR = 0.73; 95% CI, 0.57–0.92; P = .01), z‐FFMI (OR = 0.34; 95% CI, 0.17–0.68; P < .01), and body fat mass index z‐score (OR = 0.39; 95% CI, 0.17–0.91; P = .03) were significantly associated with severe malnutrition. There was no significant difference in SPhA across SGA groups; however, a higher z‐IR (poorer cell health) significantly increased the odds of severe malnutrition (OR = 2.75; 95% CI, 1.27–6.03; P = .02). Conclusion In ILD patients, malnutrition and loss of FFM negatively impact the ability to perform activities of daily living.