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Pancreatectomy, Islet Cell Transplantation, and Nutrition Considerations
Author(s) -
Narayanan Siddharth,
Bhutiani Neal,
Adamson Dylan T.,
Jones Christopher M.
Publication year - 2021
Publication title -
nutrition in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 71
eISSN - 1941-2452
pISSN - 0884-5336
DOI - 10.1002/ncp.10578
Subject(s) - medicine , transplantation , intensive care medicine , diabetes mellitus , islet , pancreatectomy , pancreatitis , perioperative , islet cell transplantation , type 2 diabetes , glucose homeostasis , disease , acute pancreatitis , type 1 diabetes , parenteral nutrition , insulin , insulin resistance , surgery , endocrinology , pancreas
Pancreatic islet transplantation is a reliable approach for treating insulin‐deficient diabetes. This established β‐cell replacement approach has shown considerable improvements in the last 2 decades. It has helped achieve metabolic homeostasis and safe outcomes for a subset of patients with type 1 diabetes and severe pancreatitis. Nutrition support, until recently, was considered as a secondary factor, merely identified as a means of providing all the necessary nutrients for such patients. However, new literature suggests that several factors, such as the route, timing, quantity, and composition of all the nutrients administered, have key disease‐altering properties and are vital during the perioperative management of such patients. This review will highlight the benefits of performing the clinical islet transplantation on a subgroup of patients with type 1 diabetes and pancreatitis and summarize new data that identify the pivotal role of nutrition support as a critical intervention in their management.