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Clinical Effects of a Pectin‐Containing Oligomeric Formula in Tube Feeding Patients: A Multicenter Randomized Clinical Trial
Author(s) -
Maruyama Michio,
Goshi Satoshi,
Kashima Yasushige,
Mizuhara Akihiro,
Higashiguchi Takashi
Publication year - 2020
Publication title -
nutrition in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 71
eISSN - 1941-2452
pISSN - 0884-5336
DOI - 10.1002/ncp.10392
Subject(s) - medicine , diarrhea , incidence (geometry) , enteral administration , parenteral nutrition , randomized controlled trial , defecation , clinical trial , gastroenterology , surgery , physics , optics
Background A pectin‐containing oligomeric formula (POF) is a unique type of enteral formula that transforms from a liquid to a gel after reacting with gastric acid. Reports on its clinical effects have been limited. The present study was conducted to examine and verify the clinical effects of POF. Methods The study subjects were 201 stable patients receiving intragastric tube feeding. They were randomized into 2 groups to receive either POF or a standard polymeric formula (SPF) as a control. The duration of observation was 1 week. Analyses were conducted for the incidence of predefined composite events, including diarrhea, defecation treatments, and other enteral nutrition (EN) management–related events. Results Composite events occurred in 15 of 98 patients in the POF group and 30 of 100 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group ( P = 0.011). In particular, diarrhea occurred in 2 patients in the POF group and 13 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group ( P = 0.003). Conclusions The results of this study suggest that POF is less likely to cause EN‐related events, especially diarrhea, than SPF is.