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Magnetization transfer studies of the fast and slow tissue water diffusion components in the human brain
Author(s) -
Mulkern Robert V.,
Vajapeyam Sridhar,
Haker Steven J.,
Maier Stephan E.
Publication year - 2005
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.939
Subject(s) - magnetization transfer , diffusion , magnetization , nuclear magnetic resonance , chemistry , diffusion imaging , pulse (music) , extracellular , signal (programming language) , amplitude , analytical chemistry (journal) , materials science , diffusion mri , magnetic resonance imaging , physics , thermodynamics , chromatography , medicine , optics , magnetic field , radiology , biochemistry , quantum mechanics , detector , computer science , programming language
Magnetization transfer (MT) properties of the fast and slow diffusion components recently observed in the human brain were assessed experimentally. One set of experiments, performed at 1.5 T in healthy volunteers, was designed to determine whether the amplitudes of fast and slow diffusion components, differentiated on the basis of biexponential fits to signal decays over a wide range of b ‐factors, demonstrated a different or similar magnetization transfer ratio (MTR). Another set of experiments, performed at 3 T in healthy volunteers, was designed to determine whether MTRs differed when measured from high signal‐to‐noise images acquired with b ‐factor weightings of 350 vs 3500 s/mm 2 . The 3 T studies included measurements of MTR as a function of off‐resonance frequency for the MT pulse at both low and high b ‐factors. The primary conclusion drawn from all the studies is that there appears to be no significant difference between the magnetization transfer properties of the fast and slow tissue water diffusion components. The conclusions do not lend support to a direct interpretation of the ‘components’ of the biexponential diffusion decay in terms of the ‘compartments’ associated with intra‐ and extracellular water. Copyright © 2004 John Wiley & Sons, Ltd.

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