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Methodological standardization for a multi‐institutional in vivo trial of localized 31 P MR spectroscopy in human cancer research. In vitro and normal volunteer studies
Author(s) -
AriasMendoza F.,
Zakian K.,
Schwartz A.,
Howe F. A.,
Koutcher J. A.,
Leach M. O.,
Griffiths J. R.,
Heerschap A.,
Glickson J. D.,
Nelson S. J.,
Evelhoch J. L.,
Charles H. C.,
Brown T. R.
Publication year - 2004
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.915
Subject(s) - in vivo , phosphocreatine , in vivo magnetic resonance spectroscopy , standardization , nuclear magnetic resonance spectroscopy , quality assurance , medical physics , medicine , nuclear magnetic resonance , magnetic resonance imaging , computer science , pathology , biology , radiology , physics , external quality assessment , microbiology and biotechnology , operating system , energy metabolism
A multi‐institutional group has been created to demonstrate the utility of in vivo 31 P magnetic resonance spectroscopy ( 31 P‐MRS) to study human cancers in vivo . This review is concerned with the novel problems concerning quality control in this large multinational trial of 31 P MRS. Our results show that the careful and systematic performance of the quality control tests depicted here (standardized dual 1 H/ 31 P tuned radiofrequency probe, quality control procedures, routine use of 1 H irradiation while acquiring 31 P MR signals) has ensured comparable results between the different institutions. In studies made in vitro , the root‐mean‐square error was 3.6 %, and in muscle of healthy volunteers in vivo the coefficients of variance for the ratios phosphocreatine/nucleotide‐triphosphates, phosphocreatine/noise and nucleotide‐triphosphate/noise were 12.2, 7.0 and 10.8 %, respectively. The standardization of the acquisition protocol for in vivo ‐localized 31 P MR spectroscopy across the different institutions has resulted in comparable in vivo data, decreasing the possible problems related to a research study carried out under a multi‐institutional setting. Copyright © 2004 John Wiley & Sons, Ltd.