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Biomedical applications of 7 Li NMR
Author(s) -
Komoroski Richard A.
Publication year - 2005
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.914
Subject(s) - neuroscience , mechanism (biology) , chemistry , nuclear magnetic resonance , psychology , physics , quantum mechanics
The biomedical applications of 7 Li MRS and MRI have been progressing slowly. The interest derives primarily from the clinical use of Li to treat bipolar disorder. One area of concern is the nature of ionic transport and binding, so as to elucidate the mechanism(s) of therapeutic action and toxicity. Another is the development of a non‐invasive, in vivo analytical tool to measure brain Li concentration and environment in humans, both as an adjunct to treatment and as a mechanistic probe. Here we review the most recent progress toward these goals. Copyright © 2005 John Wiley & Sons, Ltd.